HB-086 is a 31 kDa secreted monomeric protein which promotes neurite outgrowth from dorsal root ganglion cultures. In the central nervous system, HB-086 promotes glial differentiation.
The receptor and exact mechanism of action is unknown, but lately HB-086 was shown to use the gp130 co-receptor as an upstream transducer of Jak-STAT3 signaling1,2.
HB-086 is a strong therapeutic candidate for peripheral neuropathy and associated pain with potential disease modifying properties3.
HB-097 is a ≈30 kDa secreted protein with approximately 40% sequence homonology to HB-086.
HB-097 has been shown to induce in vitro neurite outgrow from dorsal root ganglions via the JAK-STAT3 and MEK-ERK pathway4.
The neuroprotective properties of the protein were investigated in a rodent ototoxicity hearing loss model4.
1 Nishino et al. Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. The EMBO Journal (2004) 23, 1998–200.
2 Jørgensen et al. Characterization of Meteorin—An Evolutionary Conserved Neurotrophic Factor. J Mol Neurosci. (2009);39(1-2):104-16.
3 Jørgensen et al. Meteorin reverses hypersensitivity in rat models of neuropathic pain. Exp Neurol. (2012);237(2):260-6.
4 Jørgensen et al. Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo. Exp Neurol. (2012)